If you would like to measure longer, reduce levels of inflammation throughout your body and delay the onset of age-related diseases, you ought to eat less food, say researchers.
According to a study, published within the journal Cell, researchers from US and China provided the foremost detailed report of the cellular effects of a calorie-restricted diet in rats.
While the advantages of caloric restriction have long been known, the new results show how this restriction can protect against aging in cellular pathways.
"We already knew that calorie restriction increases lifetime , but now we've shown all the changes that occur at a single-cell level to cause that," said study senior author Juan Carlos Izpisua Belmonte from the Salk Institute within the US
"This gives us targets that we may eventually be ready to act on with drugs to treat aging in humans," Belmonte added.
For the findings, the research team compared rats who ate 30 per cent fewer calories with rats on normal diets.
The diet of animals within the age bracket of 18-27 months was controlled. (In humans, this is able to be roughly like someone following a calorie-restricted diet from the age of fifty to 70.)
The research team isolated and analysed a complete of 168,703 cells from 40 cell types within the 56 rats from starting also as during the conclusion of the diet. The cells came from fat tissues, liver, kidney, aorta, skin, bone marrow, brain and muscle.
In each isolated cell, the researchers used single-cell genetic-sequencing technology to live the activity levels of genes.
They also checked out the general composition of cell types within any given tissue. Then, they compared old and young mice on each diet.
Many of the changes that occurred as rats on the traditional diet grew older didn't occur in rats on a restricted diet; even in adulthood , many of the tissues and cells of animals on the diet closely resembled those of young rats.
Overall, 57 per cent of the age-related changes in cell composition seen within the tissues of rats on a traditional diet weren't present within the rats on the calorie restricted diet, the study said.
"This approach not only told us the effect of calorie restriction on these cell types, but also provided the foremost complete and detailed study of what happens at a single-cell level during aging," said study researcher Guang-Hui Liu from Chinese Academy of Sciences in China.
According to the study, a number of the cells and genes most suffering from the diet associated with immunity, inflammation and lipid metabolism.
The number of immune cells in nearly every tissue studied dramatically increased as control rats aged but wasn't suffering from age in rats with restricted calories.
In brown fat (a sort of fat tissue) a calorie-restricted diet reverted the expression levels of the many anti-inflammatory genes to those seen in young animals, the research said.