New method discovered to test the quality of donor kidney, now transplantation will be safer

New method discovered to test the quality of donor kidney, now transplantation will be safer

There is a similar shortage of kidney donors in the country and the world. There is doubt about the quality of the kidney that is available for transplant. To overcome this problem, researchers have developed a new method, by which the quality of kidney can be known before transplant. This will help increase the number of usable donor kidneys. The study is published in the journal Optics Express.

Mingxing Sui, affiliated with Changhai Hospital in Shanghai, China, who led the research team, said there is currently no way to accurately assess donor kidney injury. If this is possible, the outcome of the transplant can be predicted and the risk of rejection in transplant patients can be reduced. That's why we wanted to find a new way to determine the quality of the donor kidney without any operation (non-invasively).

Researchers have, for the first time, used surface-enhanced Raman scattering (SERS) to simultaneously detect two susceptible kidney injury biomarkers. He also pointed out that SERS made spectroscopy more practical for clinical use.

Quality can be assessed

Sui explained that this is a very sensitive SERS-based multiplexing technique, which reveals even the smallest changes in the expression of biomarkers associated with injury to the donor kidney. This allows the donor kidney to be evaluated for its quality for clinical use.

When the kidney of a deceased person is donated, a biopsy is done to check the health of the kidney. Not only is this procedure invasive (through the hole) more time consuming, it can also damage many donor kidneys. The research also revealed that the findings of a biopsy may not always predict how well the kidney will function after a transplant.

Recently researchers have identified leukocyte peptidase inhibitor (SLPI) and interleukin 18 (IL-18) secreted in blood and urine as biomarkers. It can be used for targeted evaluation of kidney injury.

Although several methods have been tried for the identification of these biomarkers, they all have limited sensitivity, lack of multiplexing, complexity of sample preparation or high cost.

Sui's research team wanted to find out whether SERS might be a better way to identify these biomarkers. With this new vibrational spectroscopy technique, single molecule sensitivity can be easily detected and multiple biomarkers can be identified in a single experiment.

What's special about the new method

In this, Raman scattering is enhanced using nanostructures. This occurs when molecules are absorbed onto a metal surface. This scattering produces a kind of spectral fingerprint, unique to each molecule.

However, for SERS to be taken out of the laboratory for clinical use, it needed to improve its sensitivity and also to simplify its production.

The researchers met this need with a new hybrid SERS substrate, which combines gold nanomolecules with a new 2D nanomaterial called black phosphorus.

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Tonga Volcano: 'Terrifying' scene captured in satellite pictures, see how giant volcano erupted under sea, panic for many countries

Tonga Volcano: 'Terrifying' scene captured in satellite pictures, see how giant volcano erupted under sea, panic for many countries

In the island country of Tonga ( Tonga Volcano ), the situation became worrying after a sudden volcanic eruption inside the sea on Saturday . The sound of volcanic eruption was heard in many neighboring countries. Videos and satellite pictures of this incident are being shared fiercely on social media since evening ( Volcano Eruption ) . In which a very dangerous scene can be seen. Whereas there is a video in which the beach area after the explosion is seen to be completely submerged in water. At the time of the incident, it seemed as if a bomb had exploded.

Ashes and small pebbles were raining everywhere, while the sky was covered in darkness. Smoke and gas were also seen coming out of the water (Tonga Volcano New Zealand). After the volcanic eruption, a tsunami warning was issued from nearby countries New Zealand, Fiji, Japan, Australia and Samoa to Alaska in the US, although the tsunami threat had started to subside by Sunday, but how much damage has been done to Tonga so far (Tonga Volcano is Located Where). It could not be estimated.

New Zealand will help soon
New Zealand has said that it is monitoring the situation closely. And as the water waves subside, the neighboring country will extend help to Tonga (Tonga Volcano Eruption Aash Cloud). Prime Minister Jacinda Ardern said that the capital of Tonga, Nuku'Olfa, had suffered a lot. But there is no news of any injury or death (Tonga Volcano Eruption Tsunami Warning). He has said this at a time when countries and humanitarian groups in the Pacific are trying to contact Tonga. Telephone and internet services were snapped here after the incident. Due to which about 105,000 people have been affected.

high plume of smoke was observed
Satellite images showed that plumes of smoke caused by the volcanic eruption were seen up to about 20 kilometers (12 mi) above sea level (Tonga Volcano Tsunami Advisory). Boats parked on the seashore were washed away in the water and people's houses were drowned. Residents were sent to higher places in time. Tsunamis occurred in Tonga, as well as tsunami waves were seen in Australia and Japan (Tonga Volcano Satellite Video). US Secretary of State Antony Blinken said on Twitter that he is 'deeply concerned for the people of Tonga due to the volcanic eruption and tsunami (Tonga Volcano Latest News). America is ready to provide assistance to its neighbors in the Pacific region.

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