Pancreatic cancer will be easier to treat, chemotherapy will be more effective; side effects will also be less

Pancreatic cancer will be easier to treat, chemotherapy will be more effective; side effects will also be less

Although cancer of any organ is difficult to treat, but in the case of pancreas it is even more difficult. Because by the time it is detected, it has spread very much, that is, it has reached the advanced stage. In such a situation, the patient is hardly able to live more than a year after diagnosis. In these situations, very rapid chemotherapy remains an immediate method of treatment. But its side effects are also many. Chemotherapy has no effect on many tumors.

To combat these conditions, researchers at the Washington University School of Medicine in St. Louis have identified a drug compound that weakens pancreatic cancer cells in a way that makes them vulnerable to chemotherapy. . This means that chemotherapy has an effective effect on the tumor. The special thing is that it also has less side effects. The study is published in the journal 'Science Translational Medicine'.

Researchers have reported that studies on rats found that this drug significantly reduced the side effects of the chemotherapy cocktail Folphyrinax (a combination of folinic acid, 5-fluorouracil, irinotecan and oxaliplatin). This combination of drugs is commonly used in the treatment of pancreatic cancer.

Qian-Huat Limo, a cancer specialist and associate professor at the Washington University School of Medicine, and senior author of this research, said that given the current conditions, there is a great need for new and better therapies to treat pancreatic cancer. The powerful drugs we use now invariably cause serious side effects, making more chemotherapy almost impossible. But this new drug weakens the cancer cell, making it sensitive to this particular chemotherapy. In fact, during the experiment, it was found that the mice that were given chemotherapy with this drug looked much healthier than the mice that got chemotherapy only. This suggests that this new drug reduces the side effects of chemotherapy.

This drug, called ATI-450, is an anti-inflammatory and is also undergoing clinical trials for the treatment of rheumatoid arthritis. Folphyrinax is a frontline treatment for pancreatic cancer, but its use has been observed to shrink tumors in only one in three patients. Not only this, this limited effect also lasts only for six to seven months. Common side effects include nausea, vomiting, diarrhea, fatigue, hair loss, anemia, and loss of appetite. It was discovered that there is a molecule called MK2, which helps pancreatic tumor cells to evade chemotherapy. This molecule is very active in pancreatic cancer cells, which modulates the signaling of chemotherapy, so that the cancer cells survive.

The ATI-450 is also special because it is an MK2 inhibitor. Therefore, when the new drug inhibited the functioning of MK2, the effect of chemotherapy was greater in mice. It was found that when chemotherapy was given with ATI-450 and chemotherapy was given without ATI-450, chemotherapy with ATI-450 reduced tumor size more. What's more, mice treated with this combination lived an average of 41 days after chemotherapy, while mice receiving chemotherapy alone lived an average of 28 days. This new method of treatment not only increased life expectancy but also reduced side effects.

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Tonga Volcano: 'Terrifying' scene captured in satellite pictures, see how giant volcano erupted under sea, panic for many countries

Tonga Volcano: 'Terrifying' scene captured in satellite pictures, see how giant volcano erupted under sea, panic for many countries

In the island country of Tonga ( Tonga Volcano ), the situation became worrying after a sudden volcanic eruption inside the sea on Saturday . The sound of volcanic eruption was heard in many neighboring countries. Videos and satellite pictures of this incident are being shared fiercely on social media since evening ( Volcano Eruption ) . In which a very dangerous scene can be seen. Whereas there is a video in which the beach area after the explosion is seen to be completely submerged in water. At the time of the incident, it seemed as if a bomb had exploded.

Ashes and small pebbles were raining everywhere, while the sky was covered in darkness. Smoke and gas were also seen coming out of the water (Tonga Volcano New Zealand). After the volcanic eruption, a tsunami warning was issued from nearby countries New Zealand, Fiji, Japan, Australia and Samoa to Alaska in the US, although the tsunami threat had started to subside by Sunday, but how much damage has been done to Tonga so far (Tonga Volcano is Located Where). It could not be estimated.

New Zealand will help soon
New Zealand has said that it is monitoring the situation closely. And as the water waves subside, the neighboring country will extend help to Tonga (Tonga Volcano Eruption Aash Cloud). Prime Minister Jacinda Ardern said that the capital of Tonga, Nuku'Olfa, had suffered a lot. But there is no news of any injury or death (Tonga Volcano Eruption Tsunami Warning). He has said this at a time when countries and humanitarian groups in the Pacific are trying to contact Tonga. Telephone and internet services were snapped here after the incident. Due to which about 105,000 people have been affected.

high plume of smoke was observed
Satellite images showed that plumes of smoke caused by the volcanic eruption were seen up to about 20 kilometers (12 mi) above sea level (Tonga Volcano Tsunami Advisory). Boats parked on the seashore were washed away in the water and people's houses were drowned. Residents were sent to higher places in time. Tsunamis occurred in Tonga, as well as tsunami waves were seen in Australia and Japan (Tonga Volcano Satellite Video). US Secretary of State Antony Blinken said on Twitter that he is 'deeply concerned for the people of Tonga due to the volcanic eruption and tsunami (Tonga Volcano Latest News). America is ready to provide assistance to its neighbors in the Pacific region.

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