World Parkinson’s Day 2024: Can genetic testing estimate the chance of developing the degenerative brain disease?
A complicated neurological disorder called Parkinson’s disease (PD) is characterised by gradual movement dysfunction. The underlying aetiology of this condition is a complex interaction between genetic predisposition and environmental variables, even though clinical diagnosis depends on a thorough history and examination.
Dr. Richa Singh, a consultant neurologist at Ruby Hall Clinic in Puna, claims that genetic testing has become a useful method for identifying PD-related mutations. It’s important to realise, however, that a genetic predisposition does not ensure that Parkinson’s disease will manifest. On the other hand, immunity to the illness is not conferred by the lack of genetic markers. Because genetic testing is not a reliable way to confirm or rule out Parkinson’s disease (PD), it is rarely included in standard studies.
Single gene mutations have been related to Parkinson’s disease (PD) in a limited number of patients, especially in those with younger onset or familial forms of the illness. However, the probability of acquiring Parkinson’s disease (PD) is still unknown, even in people with recognised mutations. Furthermore, a number of factors of unknown relevance make it difficult to interpret genetic testing, requiring professional analysis and guidance.
Genetic testing may indicate a modestly elevated risk for PD in asymptomatic people with a family history of the disease. Since there are no clinical studies or medicines available to prevent the illness in this group, it is still impossible to predict who will get it. Therefore, future health outcomes are not determined by an individual’s genetic composition.
People who are worried about Parkinson’s disease need to talk to medical specialists. Comprehensive genetic counselling is necessary both before and after testing, if genetic testing is advised. This guarantees a thorough comprehension of the findings and their consequences, while also recognising the intrinsic intricacies of genetic risk assessment.
Genetic testing may identify possible PD predispositions, but it is not very effective in predicting an individual’s likelihood of developing the illness.
